1. With relevance to sex determination in humans, discuss: i) X chromosome inactivation; and ii) Testicular feminization (50 marks).

 

  1. Discuss the following mutations with reference to specific genetic disorders: i) Faulty DNA repair; ii) Gain-of-function; and iii) Trinucleotide repeats (50 marks).

 

  1. Explain the epigenetic mechanisms that underpin gene expression (50 marks).

 

  1. Discuss, using relevant examples, the following factors that affect Hardy-Weinberg equilibrium and shape diversity in a population: i) Natural selection, ii) Genetic drift; and iii) Migration (50 marks).