The available data show that all psychotropic agents are associated with a risk of hepatotoxicity[34]. Most of the cases of DILI are mild, and liver tests normalize after drug withdrawal. Nevertheless, sometimes the consequences are very severe, leading to death or liver transplantation
Drugs reported to cause fatty liver include total parenteral nutrition, methotrexate (Rheumatrex), griseofulvin (Grifulvin V), tamoxifen (Nolvadex), steroids, valproate (Depakote), and amiodarone (Cordarone). In certain situations, fatty liver alone can be life threatening
Once liver function impairment is found in the baseline period, it is recommended to use antipsychotic medication that has low doses or metabolize less through livers (for instance, sulpiride, amisulpride, and paliperidone)
