Pathogenesis. The continuous mucosal injury due to long-standing H. pylori infection, leads to atrophy of stomach. This continuous pathological process results in erosion or ulceration of the mucosa leading to the destruction of the glandular layer and followed by fibrous replacement

 

Helicobacter pylori acquisition is the main cause of chronic gastritis in humans. In up to half of the infected subjects, chronic gastritis progresses to atrophic gastritis and intestinal metaplasia. During this course, various mechanisms are triggered that may contribute to the pathogenesis of gastric cancer

 

Gastritis is a condition that inflames the stomach lining (the mucosa), causing belly pain, indigestion (dyspepsia), bloating and nausea. It can lead to other problems. Gastritis can come on suddenly (acute) or gradually (chronic). Medications and dietary changes can reduce stomach acid and ease gastritis symptoms

: the physiology of abnormal states specifically : the functional changes that accompany a particular syndrome or disease.